PittsburghV1, France, Analysis, bibRecord, 000583

Development of prognostic tools in pulmonary arterial hypertension: Lessons from modern day registries : Scoring in thrombotic cardiovascular disease

Identifieur interne : 000583 ( France/Analysis ); précédent : 000582; suivant : 000584

Development of prognostic tools in pulmonary arterial hypertension: Lessons from modern day registries : Scoring in thrombotic cardiovascular disease

Auteurs : Raymond L. Benza [États-Unis] ; Mardi Gomberg-Maitland [États-Unis] ; Adaani E. Frost [États-Unis] ; Robert P. Frantz [États-Unis] ; Marc Humbert [France] ; Michael D. Mcgoon [États-Unis]

Source :

Thrombosis and haemostasis [ 0340-6245 ] ; 2012.

RBID : Pascal:13-0023293

Descripteurs français

Pascal (Inist)
- Hypertension artérielle pulmonaire, Pronostic, Artère, Registre, Facteur risque, Survie, Facteur prédictif.

English descriptors

KwdEn :
- Artery, Predictive factor, Prognosis, Pulmonary hypertension, Register, Risk factor, Survival.

Abstract

Pulmonary arterial hypertension (PAH) is characterised by increased pressure in the pulmonary arteries leading to right-sided ventricular failure, and death. Identification of factors that affect patient survival is important to improve patient management and outcomes. The first registry to evaluate survival and develop a prognostic model was the National Institutes of Health (NIH) registry in 1981. Importantly this prognostic model is based on data collected prior to availability of PAH-targeted therapies and does not reflect survival rates for treated patients. Since the 1980s, however, four modern registries of PAH now exist which compensate for the NIH equations shortcomings and include the French National registry, Pulmonary Hypertension Connection registry, the Mayo registry, and the Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL). The similarities and difference in these registries are highlighted in this review and although similar in many respects, the four registries vary in patient population, including the numbers of newly and previously diagnosed patients, as well as the era of observation, period of survival, and timing of assessment of potential predictive factors. Despite this, the predictive factors identified in each registry and described in detail within the body of this manuscript share surprising homology in that disease aetiology, patient gender and factors reflective of right heart failure are integral in depicting survival. Future modifications of modern prognostic equations should be an ongoing goal of the PAH community in order to provide increased accuracy with identification of novel risk factors and prediction of disease course.

Affiliations:

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Pascal:13-0023293

Le document en format XML

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<front><div type="abstract" xml:lang="en">Pulmonary arterial hypertension (PAH) is characterised by increased pressure in the pulmonary arteries leading to right-sided ventricular failure, and death. Identification of factors that affect patient survival is important to improve patient management and outcomes. The first registry to evaluate survival and develop a prognostic model was the National Institutes of Health (NIH) registry in 1981. Importantly this prognostic model is based on data collected prior to availability of PAH-targeted therapies and does not reflect survival rates for treated patients. Since the 1980s, however, four modern registries of PAH now exist which compensate for the NIH equations shortcomings and include the French National registry, Pulmonary Hypertension Connection registry, the Mayo registry, and the Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL). The similarities and difference in these registries are highlighted in this review and although similar in many respects, the four registries vary in patient population, including the numbers of newly and previously diagnosed patients, as well as the era of observation, period of survival, and timing of assessment of potential predictive factors. Despite this, the predictive factors identified in each registry and described in detail within the body of this manuscript share surprising homology in that disease aetiology, patient gender and factors reflective of right heart failure are integral in depicting survival. Future modifications of modern prognostic equations should be an ongoing goal of the PAH community in order to provide increased accuracy with identification of novel risk factors and prediction of disease course.</div>
</front>
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Development of prognostic tools in pulmonary arterial hypertension: Lessons from modern day registries : Scoring in thrombotic cardiovascular disease

Development of prognostic tools in pulmonary arterial hypertension: Lessons from modern day registries : Scoring in thrombotic cardiovascular disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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